Peptide loading of nascent MHC class I molecules.
نویسندگان
چکیده
A critical molecular interaction during assembly of the major histocompatibility complex (MHC) class I molecules takes place between the heavy chain and the transporter-associated with antigen-processing (TAP) complex. The recent mapping of regions of the heavy chain involved in the binding to TAP suggests a complex molecular interaction essential for the cell surface expression of the MHC class I. The advances made in understanding the TAP-MHC class I interaction are reviewed and discussed here.
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عنوان ژورنال:
- Archivum immunologiae et therapiae experimentalis
دوره 49 3 شماره
صفحات -
تاریخ انتشار 2001